Abstract Search

ea0098b16 | Basic Science | NANETS2023

Chemotherapy-mediated upregulation of SSTR2 in NET tumors in mice and in tumor biopsies from lung- and gastroenteropancreatic-NET patients

Merlin Marine A. , Deshaies Isabelle , Joubert Philippe , Beauregard Jean-Mathieu , Shah Girish M.

Background: The peptide receptor radionuclide therapy (PRRT) is recommended for somatostatin receptors (SSTR) positive neuroendocrine tumors (NET). However, complete remissions with PRRT remain anecdotal and NET patients with low SSTR-positivity are excluded from this treatment. Hence, any approach to increase SSTR2 expression can improve therapeutic efficacy of PRRT. Based on previous in vitro studies with NET cell lines, we hypothesize that a treatm...

2 shares

ea0098b24 | Basic Science | NANETS2023

PARP inhibitors potentiate chemotherapy of NET cells and tumors and PAPR1-knockdown suppresses growth of NET tumors in mice#

Montoni Alicia , Shah Rashmi G. , Decobert Marc , Rajawat Jyotika , Richard Veronique , Merlin Marine A. , Girish M. Shah and

Background: In mammalian cells, poly(ADP-ribose) polymerase-1 (PARP1) is among the earliest proteins to reach the site of DNA damage and play key roles in different cellular responses ranging from DNA repair to cell death. PARP-inhibitors are recommended in mono or combination therapy for a subset of breast and ovarian cancers with BRCAness type of DNA repair deficiency. In addition, current clinical trials are examining whether PARP-inhibitors can potentiate the efficacy of c...

0 shares

Endocrine Abstracts

Chemotherapy-mediated upregulation of SSTR2 in NET tumors in mice and in tumor biopsies from lung- and gastroenteropancreatic-NET patients

PARP inhibitors potentiate chemotherapy of NET cells and tumors and PAPR1-knockdown suppresses growth of NET tumors in mice#

BiosciAbstracts